The athlete entered the previous US Open as the 26th seed.
The tennis professional disclosed he thought about ending his career due to severe back issues during the season.
The 27-year-old, who has reached a career-high ranking of world number three, finished as runner-up to Novak Djokovic at both the 2021 French Open and the 2023 Australian Open.
Now ranked 36th in the world after a limited schedule post a early exit in New York in August, Tsitsipas indicated continuous medical care has begun yielding encouraging progress.
"My greatest anticipation lies in seeing how my training responds during actual training with regard to my back," commented Tsitsipas.
"The biggest fear was whether I was able to finish a match," he added, noting the injury had troubled him "for the past six to eight months."
"I kept asking, 'Can I compete another contest without discomfort?'"
"It was genuinely scary after the defeat at the US Open [to Germany's Daniel Altmaier]. I could not to walk for two days. That's when you begin to question your career's future."
Tsitsipas further mentioned satisfaction regarding the present treatment regimen after finishing an extended period of off-season preparation completely pain-free.
He is scheduled to compete for Greece at the team event, where they face Naomi Osaka's Japan and the British team led by Emma Raducanu. The competition will be held in Perth and Sydney in early January, the week preceding the season's first major.
"My main goal next season is to not have concerns about finishing matches," he expressed.
"It is incredibly encouraging to know you had a pre-season in good health – I wish for it to last. I aim to perform during the upcoming season and for the United Cup.
"The effort is invested. The most important thing is complete faith in my ability to get back to where I was. I will try all means to make it happen."
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